| Description | TLR7/8 agonist 8 (compound 24m) is a potent dual agonist for toll-like receptors 7 and 8 (TLR7/8), exhibiting half-maximal effective concentrations (EC50s) of 27 nM for human TLR7 (hTLR7) and 12 nM for human TLR8 (hTLR8). This compound has been shown to enhance the efficacy of PD-1/PD-L1 inhibitors in antitumor activity [1]. |
| Target activity | TLR7:27 nM (EC50), TLR8:12 nM (EC50) |
| molecular weight | 418.53 |
| Molecular formula | C24H30N6O |
| CAS | 2649170-16-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |