| Description | TK05 is a potent and selective leukotriene C4 synthase (LTC4S) inhibitor (IC50: 95 nM). |
| In vitro | in MM6 Cells, TK05 reduces LTC4 production in a dose-dependent manner (IC50 of 318 ± 60 nM). |
| In vivo | LTE4 levels significantly reduced by TK05 (0.12-6 mg/kg; given i.p.; only once). |
| Target activity | LTC4S:95 nM |
| molecular weight | 540.99 |
| Molecular formula | C31H25ClN2O5 |
| CAS | 1245734-61-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| References | 1. Kleinschmidt TK, et al. Tandem Benzophenone Amino Pyridines, Potent and Selective Inhibitors of Human Leukotriene C4 Synthase. J Pharmacol Exp Ther. 2015 Oct;355(1):108-16. |