| Description | Tipepidine is a non-narcotic antitussive with an antidepressant-like effect. Tipepidine reversibly inhibits dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK) ) (IC 50 = 7.0 μM) and subsequently activates VTA dopamine neurons. |
| In vivo | Tipepidine (i.p.; 10-40 mg/kg; 0.5-23 hours) significantly decreases the immobility time in the forced swimming test in ACTH-treated rats. Tipepidine (i.p.; 40 mg/kg) increases the extracellular dopamine level of the nucleus accumbens (NAc) in ACTH-treated rats [2]. Animal Model: Male Wistar rats weighting 150-240 g (5-7 weeks old) [2] Dosage: 10, 20 and 40 mg/kg. Administration: I.p.; 0.5, 5, 23 hours. Result: Decreased the immobility time in the forced swimming test in ACTH-treated rats. |
| molecular weight | 275.43 |
| Molecular formula | C15H17NS2 |
| CAS | 5169-78-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |