| Description | Tipepidine hydrochloride is a reversible inhibitor of dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) (IC50: 7.0 μM), with antidepressant-like effect. |
| In vivo | 在接受ACTH处理的大鼠中，Tipepidine（腹腔注射；10-40 mg/kg；0.5-23小时）显著减少强迫游泳测试中的不动时间。在同样条件下，Tipepidine（腹腔注射；40 mg/kg）升高了伏隔核（NAc）区域的胞外多巴胺水平[2]。 |
| Target activity | D2:7.0 μM |
| molecular weight | 311.89 |
| Molecular formula | C15H18ClNS2 |
| CAS | 1449686-84-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 50 mg/mL (160 mM) DMSO: 41.67 mg/mL (133.60 mM), Sonication is recommended. |
| References | 1. Hamasaki R, et al. Tipepidine activates VTA dopamine neuron via inhibiting dopamine D₂ receptor-mediated inward rectifying K⁺ current. Neuroscience. 2013 Nov 12;252:24-34. 2. Kawaura K, et al. Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect in the forced swimming test in adrenocorticotropic hormone-treated rats. Behav Brain Res. 2016 Apr 1;302:269-78. |