| Description | THP-PEG4-Pyrrolidine(N-Boc)-CH2OH is a polyethylene glycol (PEG) based PROteolysis TArgeting Chimera (PROTAC) linker, employed for the synthesis of PROTAC K-Ras Degrader-1, as documented in reference [1]. |
| In vitro | PROTAC K-Ras Degrader-1 is potent?K-Ras?degrader based?PROTAC, exhibits ≥70% degradation efficacy in SW1573 cells[1].PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
| molecular weight | 477.59 |
| Molecular formula | C23H43NO9 |
| CAS | 2378261-80-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. CREW, Andrew P., et al. MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. WO2019195609A2. |
THP-PEG4-Pyrrolidine(N-Boc)-CH2OH
CAS No.: 2378261-80-2
THP-PEG4-Pyrrolidine(N-Boc)-CH2OH is a polyethylene glycol (PEG) based PROteolysis TArgeting Chimera (PROTAC) linker, em
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