| Description | Thiamine nitrate (Vitamin B1 nitrate) is an essential vitamin, and can enhance normal neuronal actives. |
| In vitro | 在杂交纯合KO和KI小鼠血液中，相比WT小鼠（0.796±0.259 μM），采用常规饮食喂养7周后，Thiamine 水平分别下降至0.058±0.051 μM和0.126±0.092 μM。当WT和杂交纯合KO及KI小鼠采用限Thiamine 饮食（Thiamine ：0.60 mg/100 g食物）喂养时，5天和14天的血液Thiamine 浓度分别显著降至0.010±0.009 μM和0.010±0.006 μM，与WT小鼠（0.609±0.288 μM）相比。WT小鼠采用常规饮食喂养时，脑组织匀浆中的Thiamine 浓度为3.81±2.18 nmol/g湿重，而KO和KI小鼠分别为1.33±0.96 nmol/g湿重和2.16±1.55 nmol/g湿重。值得注意的是，与WT（3.65±1.02 nmol/g湿重）相比，限Thiamine 饮食（Thiamine ：0.60 mg/100 g食物）喂养5天和14天的KO及KI小鼠脑组织匀浆中Thiamine 浓度分别稳定下降至0.95±0.72 nmol/g湿重和1.11±0.24 nmol/g湿重，在小鼠出现疾病表型之前[2]。 |
| Synonyms | 硝酸硫胺, Vitamin B1 nitrate |
| molecular weight | 327.36 |
| Molecular formula | C12H17N5O4S |
| CAS | 532-43-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 4.62 mg/mL (14.1 mM), Sonication is recommended. |
| References | 1. Kenneth Osiezagha, et al.Thiamine Deficiency and Delirium. Innov Clin Neurosci. 2013 Apr; 10(4): 26-32. 2. Kaoru Suzuki, et al. High-dose thiamine prevents brain lesions and prolongs survival ofSlc19a3-deficient mice. PLoS One. 2017; 12(6): e0180279. |