| Description | Thermospermine is a structural isomer of spermine and plays a role in the repression of xylem differentiation. Thermospermine can be used in studies about acting as a plant growth regulator and serving in the control of wood biomass production. |
| In vitro | The mutant defective in the biosynthesis of thermospermine, ACL5, shows a dwarf phenotype with excess xylem vessels in Arabidopsis thaliana. Exogenous supply of thermospermine remarkably represses xylem differentiation in the root of seedlings. Rice showed up-regulation of phloem-expressed genes, OsHB5 and OsYSL16, by one-day treatment with thermospermine.Expression of OsPAO2 and OsPAO6, encoding extracellular polyamine oxidase whose orthologs are not present in Arabidopsis, was induced by both thermospermine and spermine[3]. |
| Synonyms | N'-[3-(3-aminopropylamino)propyl]butane-1,4-diamine, 1,12-Diamino-4,8-diazadodecane |
| molecular weight | 202.34 |
| Molecular formula | C10H26N4 |
| CAS | 70862-11-2 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 55 mg/mL (271.82 mM) |
| References | 1. Takano A, Kakehi J, Takahashi T. Thermospermine is not a minor polyamine in the plant kingdom. Plant Cell Physiol. 2012 Apr;53(4):606-16. 2. Takahashi T. Thermospermine: An Evolutionarily Ancient but Functionally New Compound in Plants. Methods Mol Biol. 2018;1694:51-59. 3. Miyamoto M, et al. Effect of Thermospermine on the Growth and Expression of Polyamine-Related Genes in Rice Seedlings. Plants (Basel). 2019 Aug 6;8(8):269. |