| Description | Thaspine is a potent topoisomerase IB inhibitor. Taspine downregulates VEGF expression and inhibits proliferation of vascular endothelial cells through PI3 kinase and MAP kinase signaling pathways. |
| Synonyms | Thaspine, Thaspine HCl, NSC 135784, NSC-135784, NSC135784 |
| molecular weight | 429.425 |
| Molecular formula | C22H23NO8 |
| CAS | 74578-01-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Castelli S, Katkar P, Vassallo O, Falconi M, Linder S, Desideri A. A natural anticancer agent thaspine targets human topoisomerase IB. Anticancer Agents Med Chem. 2013 Feb;13(2):356-63. PubMed PMID: 22931416. 2. Montopoli M, Bertin R, Chen Z, Bolcato J, Caparrotta L, Froldi G. Croton lechleri sap and isolated alkaloid taspine exhibit inhibition against human melanoma SK23 and colon cancer HT29 cell lines. J Ethnopharmacol. 2012 Dec 18;144(3):747-53. doi: 10.1016/j.jep.2012.10.032. PubMed PMID: 23123266. 3. Zhang Y, Zheng L, Zhang J, Dai B, Wang N, Chen Y, He L. Antitumor activity of taspine by modulating the EGFR signaling pathway of Erk1/2 and Akt in vitro and in vivo. Planta Med. 2011 Nov;77(16):1774-81. doi: 10.1055/s-0030-1271132. PubMed PMID: 21614750. 4. Zhan Y, Zhang Y, Chen Y, Wang N, Zheng L, He L. Activity of taspine isolated from Radix et Rhizoma Leonticis against estrogen-receptor-positive breast cancer. Fitoterapia. 2011 Sep;82(6):896-902. doi: 10.1016/j.fitote.2011.05.004. PubMed PMID: 21605638. |