Description | Thalidomide-O-amido-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 3) is an E3 ligase ligand-linker conjugate which is designed using Thalidomide-based cereblon ligand and a 3-unit PEG linker. This compound is synthesized specifically for utilization in PROTAC technology. |
In vitro | Thalidomide-O-amido-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 3) is composed of Degron (E3 ubiquitin ligase) and a linker, and they are used in PROTAC technology. Thalidomide-O-amido-PEG3-C2-NH2 binds to the targeting ligand to induce the target protein (including BRD4, BRD2, and BRD3) degradation[1]. |
Synonyms | Cereblon Ligand-Linker Conjugates 3, E3 Ligase Ligand-Linker Conjugates 14 |
molecular weight | 506.51 |
Molecular formula | C23H30N4O9 |
CAS | 1957236-20-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
References | 1. Methods to induce targeted protein degradation through bifunctional molecules. WO 2017007612 A1 |