| Description | Thalidomide 4-fluoride (E3 ligase Ligand 4) (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand. Thalidomide 4-fluoride can be used in the recruitment of CRBN protein. Thalidomide 4-fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1. |
| Synonyms | E3 ligase Ligand 4, 2-(2,6-二氧代-哌啶-3-基)-4-氟基-异吲哚-1,3-二酮 |
| molecular weight | 276.22 |
| Molecular formula | C13H9FN2O4 |
| CAS | 835616-60-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 199 mg/mL (720.44 mM) |
| References | 1. Nello Mainolfi, et al. Irak degraders and uses thereof. US20190192668A1. |