| Description | TH5487 is an potent inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1)( IC50 of 342 nM) |
| In vitro | TH5487以剂量依赖的方式抑制了促炎基因的表达。 |
| In vivo | TH5487（预防性腹腔注射；8-30 mg/kg；1-9小时）降低了TNFα或LPS诱导的气道中中性粒细胞的大量招募，并以时间依赖的方式减少了肺部中性粒细胞计数。TH5487中断了TNFα诱导的持续性炎症过程。 |
| Cell experiments | Cell Line:Murine airway epithelial cell line (MLE 12); Diploid human small-airway epithelial cell (hSAECs). Concentration:5 μM. Incubation Time:1 hour |
| Animal experiments | Animal Model:Eightweek-old female and male BALB/c mice. Dosage:8 mg/kg, 15 mg/kg, 30 mg/kg. Administration:Prophylactic intraperitoneally injection; 8-30 mg/kg; 1-9 hours |
| Target activity | OGG1:342 nM |
| molecular weight | 541.18 |
| Molecular formula | C19H18BrIN4O2 |
| CAS | 2304947-71-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 45 mg/mL (83.15 mM), Sonication is recommended. |
| References | 1. Visnes T, et al. Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation. Science. 2018 Nov 16;362(6416):834-839. |