| Description | TH1020 is a novel Inhibitor of Toll-Like Receptor 5 (TLR5)/Flagellin Complex with promising activity (IC50 =0.85±0.12 μm) and specificity. |
| In vivo | TH1020 was repress the expression of downstream TNF-α signaling pathways mediated by the TLR5/flagellin complex formation.?Based on molecular docking simulation, TH1020 is suggested to compete with flagellin and disrupt its association with TLR5.?TH1020 provides a much-needed molecular probe for studying this important protein-protein interaction and a lead compound for identifying novel therapeutics targeting TLR5. |
| Target activity | TLR5/flagellin complex:0.85 μM (IC50) |
| molecular weight | 453.54 |
| Molecular formula | C23H15N7S2 |
| CAS | 1841460-82-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 4.54 mg/mL (10 mM), Sonication is recommended. |
| References | 1. Lei Yan, et al. Pyrimidine Triazole Thioether Derivatives as Toll-Like Receptor 5 (TLR5)/Flagellin Complex Inhibitors. ChemMedChem. 2016 Apr 19;11(8):822-6. |