| Description | TfR-T12 acetate is a peptide binding to the transferrin receptor (TfR) and is subsequently internalized into TfR-expressing cells. |
| In vitro | SAG dihydrochloride 可与聚乙二醇化脂质衍生物3-(N-琥珀酰亚胺基辛酰氧基)氨基丙基-聚乙二醇(2000)-氨甲酰基二硬脂酰磷脂乙醇胺(NHS-PEG2000-DSPE)进行化学共轭，用作功能材料，构建多功能脂质囊泡[1]。 |
| In vivo | 在携带脑胶质瘤的小鼠中，TfR-T12 acetate 通过BBB（血脑屏障）传运，通过诱导坏死、凋亡和自噬作用，杀死脑胶质瘤和胶质瘤干细胞[2]。 |
| Synonyms | TfR-T12 acetate (344618-30-0 Free base) |
| molecular weight | 1550.78 |
| Molecular formula | C73H103N19O17S |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| References | 1. Li-Min Mu, et al. Lipid Vesicles Containing Transferrin Receptor Binding Peptide TfR-T 12 and Octa-Arginine Conjugate stearyl-R 8 Efficiently Treat Brain Glioma Along With Glioma Stem Cells. Sci Rep. 2017 Jun 14;7(1):3487. 2. Carmen Wängler, et al. In Vitro and Initial in Vivo Evaluation of (68)Ga-labeled Transferrin Receptor (TfR) Binding Peptides as Potential Carriers for Enhanced Drug Transport Into TfR Expressing Cells. Mol Imaging Biol. 2011 Apr;13(2):332-41. |