| Description | Tetrachlorohydroquinone (TCHQ) is a metabolite of the organochlorine biocide pentachlorophenol. It is cytotoxic to RTL-W1 rainbow trout liver cells (EC50 = 1.55 μM in a neutral red assay). TCHQ increases production of reactive oxygen species (ROS), inhibits apoptosis, and induces loss of the mitochondrial membrane potential and necrosis in splenocytes. |
| In vivo | In vivo, TCHQ induces glutathione (GSH) depletion in mouse liver. |
| molecular weight | 247.89 |
| Molecular formula | C6H2Cl4O2 |
| CAS | 87-87-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMF: 30 mg/mL Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/mL DMSO: 30 mg/mL Ethanol: 30 mg/mL |