| Description | Tenofovir-C3-O-C12-trimethylsilylacetylene (ammonium) displays a prolonged half-life (t1/2) compared to tenofovir in human liver microsomes. Moreover, it demonstrates potent in vitro anti-HIV activity and improves in vivo pharmacokinetic properties. |
| Synonyms | Tenofovir-C3-O-C12-trimethylsilylacetylene ammonium |
| molecular weight | 626.855 |
| Molecular formula | C29H55N6O5PSi |
| CAS | 2611373-74-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Pribut N, et al. ω-Functionalized Lipid Prodrugs of HIV NtRTI Tenofovir with Enhanced Pharmacokinetic Properties. J Med Chem. 2021 Sep 9;64(17):12917-12937. |
Tenofovir-C3-O-C12-trimethylsilylacetylene ammonium
CAS No.: 2611373-74-9
Tenofovir-C3-O-C12-trimethylsilylacetylene (ammonium) displays a prolonged half-life (t1/2) compared to tenofovir in hum
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