| Description | Tenivastatin (Simvastatin acid) is an anti-hyperlipidemic HMG-CoA reductase inhibitor that inhibits the production of reactive oxygen species (ROS) and can be used in the study of primary hyperlipidemia. |
| In vitro | 在 hCM 和 HEK293（转染 OATP3A1）中，Simvastatin acid（0.1、1、10和20 μM；24小时）处理后，Simvastatin acid 以剂量依赖的方式使 OATP3A1 表达量在 hCM 和表达 OATP3A1 的细胞中分别降低了1.5%至90%[1]。 |
| Synonyms | L-654969, L654969, Simvastatin acid, L 654969, Simvastatin hydroxy acid |
| molecular weight | 436.58 |
| Molecular formula | C25H40O6 |
| CAS | 121009-77-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Eduardo Filipe Oliveira, et al. HMG-CoA Reductase inhibitors: an updated review of patents of novel compounds and formulations (2011-2015). Expert Opin Ther Pat. 2016 Nov;26(11):1257-1272. 2. Atilano-Roque A, et al. Characterization of simvastatin acid uptake by organic anion transporting polypeptide 3A1 (OATP3A1) and influence of drug-drug interaction. Toxicol In Vitro. 2017 Dec;45(Pt 1):158-165. |