| Description | Tenilsetam (Piperazinone) is an endonuclease modulator; a nootropic agent and advanced glycation end product (AGE) inhibitor having potential for Alzheimer's disease (AD) treatment. |
| In vitro | In vitro, tenilsetam inhibited endothelial proliferation at lower doses, while inducing apoptosis at high doses.?Leucocyte adhesion was only inhibited at high doses.?Sprouting angiogenesis of bovine retinal endothelial cells was promoted at lower doses ( |
| Synonyms | 替尼西坦, Piperazinone |
| molecular weight | 182.24 |
| Molecular formula | C8H10N2OS |
| CAS | 86696-86-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 25 mg/mL (137.18 mM) |
| References | 1. Jennifer Hoffmann , Alex Alt, Jihong Lin, Günther Lochnit,et al. Tenilsetam prevents early diabetic retinopathy without correcting pericyte loss.Thromb Haemost. 2006 Apr;95(4):689-95. 2. Gyengesi E , Liang H , Millington C , et al. Investigation Into the Effects of Tenilsetam on Markers of Neuroinflammation in GFAP-IL6 Mice[J]. Pharm Res, 2018, 35(1):22. |