| Description | Tedizolid Phosphate (TR-701FA) is an oxazolidinone-class antibiotic. Tedizolid phosphate is a phosphate ester prodrug of the active compound tedizolid. |
| In vitro | Tedizolid（TR-700，前称torezolid）是前药TR-701的活性成分，属于下一代oxazolidinone类，对包括耐甲氧西林金黄色葡萄球菌（MRSA）在内的革兰阳性菌种具有高效力[2]。相较于linezolid，Tedizolid对体外PRSP分离株具有4倍的增强效力[1]。 |
| In vivo | Tedizolid在穿透肺上皮细胞衬里液(ELF)方面表现出色。无论是通过口服还是静脉注射给予小鼠Tedizolid磷酸盐，都能有效抵抗PRSP分离株引起的系统感染。口服Tedizolid磷酸盐同样能有效对抗由PSSP菌株引发的肺炎[1]。 |
| Synonyms | TR-701FA, Torezolid phosphate, 磷酸特地唑胺 |
| molecular weight | 450.32 |
| Molecular formula | C17H16FN6O6P |
| CAS | 856867-55-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: < 1 mg/mL (insoluble or slightly soluble) DMSO: 1 mg/ml, Sonication is recommended. Ethanol: < 1 mg/mL (insoluble or slightly soluble) |
| References | 1. Choi S, et al. Antimicrob Agents Chemother. 2012, 56(9):4713-7. 2. Prokocimer P, et al. Antimicrob Agents Chemother. 2012, 56(9):4608-13. |