| Description | TCS PrP Inhibitor 13 (5-(4-Nitrophenyl)-2-Phenyl-4H-Pyrazol-3-One) is an antiprion agent inhibiting protease-resistant prion protein (PrP-res) accumulation. |
| In vitro | 在Schwannoma细胞中，施用0-500μM TCS PrP Inhibitor 13能显著减少总ERK1/2、pAKT、总FAK、Cyclin D1、PrPC的水平，并显著增加裂解caspase-3的表达。TCS PrP Inhibitor 13还显著减少了Schwannoma细胞中增殖的Ki67阳性细胞数量和总细胞数量[2]。 |
| Target activity | PrPC:3 nM (in ScN2a and F3 cells) |
| Synonyms | 5-(4-Nitrophenyl)-2-Phenyl-4H-Pyrazol-3-One |
| molecular weight | 281.27 |
| Molecular formula | C15H11N3O3 |
| CAS | 34320-83-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 88 mg/mL (312.87 mM) |
| References | 1. Kimata A, et al. New series of antiprion compounds: pyrazolone derivatives have the potent activity of inhibiting protease-resistant prion protein accumulation [published correction appears in J Med Chem. 2008 Mar 13;51(5):1503]. J Med Chem. 2007;50(21):5053-5056. 2. Provenzano L, et al. Cellular prion protein (PrPC) in the development of Merlin-deficient tumours. Oncogene. 2017;36(44):6132-6142. |