| Description | TCS 46b is a NR1A/NR2B NMDA receptor antagonist with oral activity. |
| molecular weight | 345.44 |
| Molecular formula | C22H23N3O |
| CAS | 302799-86-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 55 mg/mL (159.22 mM) Ethanol: < 34.54 mg/mL |
| References | 1. Nikam SS, Meltzer LT. NR2B selective NMDA receptor antagonists. Curr Pharm Des. 2002;8(10):845-55. doi: 10.2174/1381612024607072. PMID: 11945135. 2. Wright JL, Gregory TF, Kesten SR, Boxer PA, Serpa KA, Meltzer LT, Wise LD, Espitia SA, Konkoy CS, Whittemore ER, Woodward RM. Subtype-selective N-methyl-D-aspartate receptor antagonists: synthesis and biological evaluation of 1-(heteroarylalkynyl)-4-benzylpiperidines. J Med Chem. 2000 Sep 7;43(18):3408-19. doi: 10.1021/jm000023o. PMID: 10978188. 3. Dischino D D , Gribkoff V K , Hewawasam P , et al. Synthesis of 3H and 14C labeled (S)‐3‐(5‐chloro‐2‐methoxyphenyl)‐1,3‐dihydro‐3‐fluoro‐6‐(trifluoromethyl)‐2H‐indol‐2‐one, maxipost. An agent for post‐stroke neuroprotection[J]. Journal of Labelled Compounds and Radiopharmaceuticals, 2003, 46(2):139-149. |