| Description | TCS 1105 is a GABAA benzodiazepine receptor (BZR) ligand. TCS 1105 blocks Sema3A induced axonal growth cones collapse. TCS 1105 reduces anxiety-like behavior and enhances offensive behavior and social dominance in mice. |
| Synonyms | N-(4-fluorobenzyl)-2-(1H-indol-3-yl)-2-oxoacetamide |
| molecular weight | 296.3 |
| Molecular formula | C17H13FN2O2 |
| CAS | 185391-33-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 25 mg/ml (84.4 mM) Ethanol: < 5.93 mg/mL |
| References | 1. Xu J, et al. Anesthetics disrupt growth cone guidance cue sensing through actions on the GABAA α2 receptor mediated by the immature chloride gradient. Neurotoxicol Teratol. 2019 Jul-Aug;74:106812. 2. van der Kooij MA, et al. GABAA receptors in the ventral tegmental area control the outcome of a social competition in rats. Neuropharmacology. 2018 Aug;138:275-281. |