| Description | Tazanolast is a selective mast-cell-stabilizing drug. |
| In vitro | Tazanolast has been shown to suppress passive cutaneous anaphylaxis, Schultz-Dale reaction in isolated tracheal muscle, and experimental asthma without antagonistic actions upon histamine- and leukotriene-D4-induced contraction [1]. |
| In vivo | Tazanolast administered before ozone exposure at doses of 30, 100, or 300 mg/kg inhibits ozone-induced airway hyperresponsiveness in a dose-dependent manner. Tazanolast significantly inhibits ozone-induced airway hyperresponsiveness in guinea pigs [1]. |
| Synonyms | 他扎司特, Tazalest, TO 188, Tazanol |
| molecular weight | 289.29 |
| Molecular formula | C13H15N5O3 |
| CAS | 82989-25-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| References | 1. Igarashi A, et al. Tazanolast inhibits ozone-induced airway hyperresponsiveness in guinea pigs. Am J Respir Crit Care Med. 1998 May;157(5 Pt 1):1531-5. |