| Description | TAT-DEF-Elk-1 acetate is a cell-penetrating peptide inhibitor of ERK1/2 kinase phosphorylated Elk-1 with antitumor and antidepressant activity.TAT-DEF-Elk-1 acetate inhibits the phosphorylation of Elk-1, inhibits Elk-1 nuclear TAT-DEF-Elk-1 acetate inhibits Elk-1 phosphorylation and Elk-1 nuclear translocation, and can be used to study depression. |
| In vitro | Elk-1 在 Ser383/389 上的磷酸化具有双重功能，可触发 Elk-1 核转位和 SRE 依赖性基因表达;TAT-DEF-Elk-1（5 μM；2 小时）治疗可显著抑制 c-Fos、Zif268 和 JunB，但对 c-Jun 表达没有影响；TAT-DEF-Elk-1（5-10 μM；1 小时）特异性抑制谷氨酸诱导的 elk-1 活化，并且不会干扰 ERK、MSK-1 或 CREB 磷酸化。[1] |
| In vivo | TAT-DEF-Elk-1（腹膜内注射；1mg/kg；每日；14 天）反映了小鼠的抗抑郁功效，它降低了与参考抗抑郁药氟西汀和地昔帕明 (DMI) 相似的静止性。[2] |
| Synonyms | TAT-DEF-Elk-1 acetate（1220751-16-5 Free base）, TED acetate |
| molecular weight | 3621.19 |
| Molecular formula | C157H263N57O42 |
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Lavaur J, et al. A TAT-DEF-Elk-1 peptide regulates the cytonuclear trafficking of Elk-1 and controls cytoskeleton dynamics. J Neurosci. 2007 Dec 26;27(52):14448-58. |