| Description | Tamerit as an efficient inhibitor of oxidative burst in monocytes. |
| In vitro | 在以PMA刺激的单核细胞中，Tamerit在10-500 mg/ml的浓度范围内显著抑制氧化暴发响应，而在以大肠杆菌E. coli刺激的单核细胞中，Tamerit作为抑制剂的效率较低（抑制范围为50-500 mg/ml Tamerit）。Tamerit仅在100-500 mg/ml的浓度范围内抑制PMC的氧化暴发。Tamerit是有效的单核细胞氧化暴发抑制剂。已发现单核细胞/巨噬细胞产生的活性氧物种(ROS)对于脂多糖(LPS)驱动的几种促炎细胞因子的产生非常重要，Tamerit可能通过抑制单核细胞/巨噬细胞的氧化暴发来发挥其抗炎效应。 |
| molecular weight | 199.14 |
| Molecular formula | C8H6N3NaO2 |
| CAS | 20666-12-0 |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 5.45 mg/mL (27.39 mM), Sonication is recommended. |
| References | 1. Tomislav Jukić, Abidov M , Ihan A . A tetrahydrophthalazine derivative 'sodium nucleinate" exerts a potent suppressive effect upon LPS-stimulated mononuclear cells in vitro and in vivo.[J]. Collegium Antropologicum, 2011, 35(4):1219-23. |