| Description | T3Inh-1 is an effective and selective inhibitor of ppGalNAc-T3 with an IC50 of 7 µM. T3Inh-1 prevents breast cancer cells. T3Inh-1 reduces FGF23 hormone levels in both tissue cells and mice, without causing any toxic side effects. |
| In vitro | 在HEK细胞中，T3Inh-1 (6h)促进了FGF2的裂解。在MDA-MB231细胞中，T3Inh-1(5 µM; 24h, 48h)通过抑制迁移超过80%，侵袭减少了98%，同时对细胞增殖没有明显影响。T3Inh-1没有表现出毒性，并且不影响HEK细胞的增殖[1]。 |
| In vivo | 在野生型C57BL/6小鼠中，T3Inh-1（25, 50 mg/kg；i.p.）阻断了ppGalNAc-T3介导的FGF23糖基掩蔽，并增加了其切割率[1]。 |
| Target activity | ppGalNAc-T3:7 µM |
| molecular weight | 476.49 |
| Molecular formula | C27H20N6O3 |
| CAS | 50440-30-7 |
| Storage | |Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 4.76 mg/mL (10 mM), Sonication is recommended. |
| References | 1. Song L, et al. Inhibitor of ppGalNAc-T3-mediated O-glycosylation blocks cancer cell invasiveness and lowers FGF23 levels. Elife. 2017;6:e2405Published 2017 Mar 31. |