| Description | T-705RTP is a selective and GTP-competitive of influenza virus RNA polymerase(IC50 of 0.14 μM and a Ki of 1.52 μM), has potent anti-influenza virus activity. |
| In vitro | T-705RTP sodium and T-705RMP are detected in MDCK cells treated with T-705. influenza virus RNA polymerase activity in a dose-dependent and a GTP-competitive manner inhibited by T-705RTP sodium[1]. T-705RTP inhibits the incorporation of ATP and GTP in a competitive manner (Ki of 7.72 and 1.56 μM, respectively). T-705RTP inhibits the incorporation of CTP in a mixed-type manner(Ki of 11.3 μM), and also inhibits the incorporation of UTP in a noncompetitive manner[2]. The incorporation of a single molecule of T-705RTP (10-1000 μM) inhibits influenza virus RNA strand extension[2]. |
| Target activity | Influenza virus RNA polymerase:(ki)1.52 μM , Influenza virus RNA polymerase:0.14 μM |
| molecular weight | 529.16 |
| Molecular formula | C10H15FN3O15P3 |
| CAS | 740790-94-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Furuta Y, et al. Mechanism of action of T-705 against influenza virus. Antimicrob Agents Chemother. 2005 Mar;49(3):981-6. 2. Sangawa H, et al. Mechanism of action of T-705 ribosyl triphosphate against influenza virus RNA polymerase. Antimicrob Agents Chemother. 2013 Nov;57(11):5202-8. |