| Description | T-226296 is a antagonist of melanin concentrating hormone receptor 1 (MCHR1). |
| Synonyms | T 226296, T226296 |
| molecular weight | 402.5 |
| Molecular formula | C26H27FN2O |
| CAS | 331758-35-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Högberg T, Frimurer TM, Sasmal PK. Melanin concentrating hormone receptor 1 (MCHR1) antagonists-Still a viable approach for obesity treatment? Bioorg Med Chem Lett. 2012 Oct 1;22(19):6039-47. doi: 10.1016/j.bmcl.2012.08.025. Epub 2012 Aug 19. PubMed PMID: 22954736. 2. Saito Y, Maruyama K. Identification of melanin-concentrating hormone receptor and its impact on drug discovery. J Exp Zool A Comp Exp Biol. 2006 Sep 1;305(9):761-8. Review. PubMed PMID: 16902961. 3. Basso AM, Bratcher NA, Gallagher KB, Cowart MD, Zhao C, Sun M, Esbenshade TA, Brune ME, Fox GB, Schmidt M, Collins CA, Souers AJ, Iyengar R, Vasudevan A, Kym PR, Hancock AA, Rueter LE. Lack of efficacy of melanin-concentrating hormone-1 receptor antagonists in models of depression and anxiety. Eur J Pharmacol. 2006 Jul 1;540(1-3):115-20. Epub 2006 May 6. PubMed PMID: 16765941. 4. Kowalski TJ, Farley C, Cohen-Williams ME, Varty G, Spar BD. Melanin-concentrating hormone-1 receptor antagonism decreases feeding by reducing meal size. Eur J Pharmacol. 2004 Aug 16;497(1):41-7. PubMed PMID: 15321733. |