| Description | Syntelin is a selectively CENP-E inhibitor. Syntelin inhibited CENP-E motility in a dose-dependent manner with an IC50 value of 160 nM. Among an extensive list of mitotic kinesins examined, syntelin was found to be highly selective for CENP-E. Syntelin binds to different sites from those of GSK923295, a recently identified CENP-E ATPase inhibitor, as syntelin inhibits CENP-E mutants resistant to GSK923295 in a manner indistinguishable from that of wild type motor. Syntelin represents a novel class of CENP-E motor inhibitor. |
| molecular weight | 484.62 |
| Molecular formula | C21H20N6O2S3 |
| CAS | 438481-33-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |