| Description | SW157765 is a selective glucose transporter GLUT8 (SLC2A8) inhibitor, a prodrug of many compounds, that selectively inhibits the uptake of fluorescent 2-deoxyglucose (2DG) in SW157765-sensitive cells in a dose-dependent manner, and can be used for the study of lung cancer. |
| In vitro | SW157765 以剂量依赖性方式选择性地抑制 SW157765 敏感细胞中荧光 2-脱氧葡萄糖 （2DG）的摄取[1]。 |
| molecular weight | 331.32 |
| Molecular formula | C19H13N3O3 |
| CAS | 332063-87-3 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 10 mg/mL (30.18 mM), Sonication and heating are recommended. |
| References | 1. Pine SR, et al. Identifying therapeutic vulnerabilities in lung cancer: application of a chemistry-first approach. Transl Lung Cancer Res. 2018;7(Suppl 3):S265-S269. 2. McMillan EA, et al. Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer. Cell. 2018;173(4):864-878.e29. |