| Description | Surfactin is a potent cyclic lipopeptide biosurfactants that mediates flux of mono-and divalent cations, such as calcium, across lipid bilayer membranes, with anti-bacterial, anti-fungal, antimycoplasma and hemolytic effects. |
| In vitro | Surfactin 作为一种表面活性剂，调节单价和双价阳离子，通过脂质双层膜的流动。Surfactin能够通过最小抑制浓度（MIC）和分数抑制浓度（FIC）等抗菌实验，提升阿莫西林对禽类致病性大肠杆菌（APEC）体外活性。 |
| In vivo | 在小鸡感染模型中，surfactin与amoxicillin联合作用能够降低小鸡的死亡率及肝脏细菌载量，并调节炎症细胞因子等的表达。surfactin可作为针对AEPC感染的小鸡的一种新型抗菌增效剂。 |
| molecular weight | 1036.34 |
| Molecular formula | C53H93N7O13 |
| CAS | 24730-31-2 |
| Storage | keep away from moisture|Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 28.25 mg/mL (27.26 mM), Sonication is recommended. DMSO: 47 mg/mL (45.35 mM), Sonication is recommended. |
| References | 1. Liu J, et al. Sensitization of avian pathogenic Escherichia coli to amoxicillin in vitro and in vivo in the presence of surfactin. PLoS One. 2019 Sep 12;14(9):e0222413. 2. Wei-Chuan Chena, et al. Applications of a lipopeptide biosurfactant, surfactin, produced by microorganisms. Biochemical Engineering Journal. 103 (2015) 158-169. 3. Vollenbroich D, et al. Mechanism of inactivation of enveloped viruses by the biosurfactant surfactin from Bacillus subtilis. Biologicals. 1997 Sep;25(3):289-97. |
| Citations | 1. Bi M, Li M, Wei J, et al.Genome-scale cis-acting element (cres) editing confers Bacillus pumilus LG3145 plant-beneficial functions.iScience.2024 |