| Description | Sulfosuccinimidyl oleate sodium (Sulfo-N-succinimidyl oleate sodium) is a long-chain fatty acid that inhibits the transport of fatty acids to cells. Sulfosuccinimidyl oleate sodium is an effective, irreversible inhibitor of mitochondrial respiratory chain. Sulfosuccinimidyl oleate sodium binds to CD36 receptors on the surface of microglia. |
| In vitro | Sulfosuccinimidyl oleate（50 μM，24小时）的联合处理显著降低了LPS+IFNγ刺激的BV2细胞中NOS2和COX-2的表达。西方印迹分析显示，LPS/IFNγ刺激显著上调磷酸化p38的形式，而Sulfosuccinimidyl oleate（50 μM，24小时）的联合处理有效防止了这一变化[1]。 |
| In vivo | 在采用pMCAo模型的雄性BALB/cABom小鼠中，Sulfosuccinimidyl oleate（50 mg/kg；单次通过口腔灌胃给药）与对照组相比明显降低了脑皮层梗死面积。此外，Sulfosuccinimidyl oleate（50 mg/kg）在中风后可观察到的有益效果[1]。 |
| Synonyms | Sulfo-N-succinimidyl oleate sodium |
| molecular weight | 481.58 |
| Molecular formula | C22H36NNaO7S |
| CAS | 1212012-37-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 70 mg/mL (145.35 mM), Sonication is recommended. |
| References | 1. Dhungana H, et al. Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation. J Neuroinflammation. 2017 Dec 4;14(1):237. 2. Drahota Z, et al. Succinimidyl oleate, established inhibitor of CD36/FAT translocase inhibits complex III of mitochondrial respiratory chain. Biochem Biophys Res Commun. 2010 Jan 15;391(3):1348-51. |
Sulfosuccinimidyl oleate sodium
CAS No.: 1212012-37-7
Sulfosuccinimidyl oleate sodium (Sulfo-N-succinimidyl oleate sodium) is a long-chain fatty acid that inhibits the transp
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