| Description | Substance P(1-7) (Substance P 1-7) is the major bioactive metabolite formed after proteolytic degradation of the tachykinin substance P (SP),with anti-inflammatory, anti-nociceptive and anti-hyperalgesic effects |
| In vivo | Substance P 1-7（SP(1-7)），作为大鼠中枢神经系统（CNS）中主要的SP片段，通过黑质内注射给药。研究发现，SP(1-7)在SP注射后能在黑质区域内部生成，并且表现为一种高效的拮抗剂，针对SP诱导的反应具有明显的抑制作用。据此，提出SP(1-7)可能作为SP作用的内源性调节物。在肽类系统的自我调节机制中，生成既保持受体亲和力但不具备效能的肽段，可能是一种普遍机制[1]。 |
| Synonyms | Substance P 1-7 |
| molecular weight | 900.04 |
| Molecular formula | C41H65N13O10 |
| CAS | 68060-49-1 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Herrera-Marschitz M , Terenius L , Sakurada T , et al. The substance P(1-7) fragment is a potent modulator of substance P actions in the brain[J]. Brain Research, 1990, 521(1-2):316-320. 2. Skogh A , Lesniak A , Gaugaz F Z , et al. Impact of N -methylation of the substance P 1–7 amide on anti-allodynic effect in mice after peripheral administration[J]. European Journal of Pharmaceutical Sciences, 2017, 109. |