| Description | Substance P (1-7) 2TFA(68060-49-1(free base)) is the major bioactive metabolite formed after proteolytic degradation of the tachykinin substance P (SP),with anti-inflammatory, anti-nociceptive and anti-hyperalgesic effects |
| In vivo | SP(1-7)，作为大鼠中枢神经系统中主要的SP片段，通过黑质内注射给药。研究发现，SP(1-7)能强效地拮抗SP引发的反应，并在SP注射后于黑质内部生成。据推测，SP(1-7)是SP作用的内源性调节剂。在肽类神经系统中，生成既保留受体亲和力但不保留效能的肽片段，可能是一种自我调节的普遍机制[1]。 |
| molecular weight | 1128.08 |
| Molecular formula | C45H67F6N13O14 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 10 mM |
| References | 1. Herrera-Marschitz M , Terenius L , Sakurada T , et al. The substance P(1-7) fragment is a potent modulator of substance P actions in the brain[J]. Brain Research, 1990, 521(1-2):316-320. 2. Skogh A , Lesniak A , Gaugaz F Z , et al. Impact of N -methylation of the substance P 1–7 amide on anti-allodynic effect in mice after peripheral administration[J]. European Journal of Pharmaceutical Sciences, 2017, 109. |
Substance P (1-7) 2TFA(68060-49-1(free base))
CAS No.:
Substance P (1-7) 2TFA(68060-49-1(free base)) is the major bioactive metabolite formed after proteolytic degradation of
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