| Description | SU056 is a YB-1 inhibitor. SU056 interacts with YB-1 and inhibits and downstream proteins and pathways. SU056 can induce cell-cycle arrest, apoptosis, and inhibit cell migration in ovarian cancer cells. |
| In vitro | SU056 (0-10 μM，48小时) 抑制OVCAR3/4/5/8、SKOV3和ID8细胞的生长。SU056 (1 μM, 5-8天) 以剂量依赖方式抑制OVCAR-8和ID8细胞的集落形成。SU056 (1-5 μM，6小时) 阻止OVCAR8、SKOV3和ID8细胞在sub G1阶段和G1阶段停滞。SU056 (0-1 μM，12小时) 抑制OVCAR8、SKOV3和ID8细胞的迁移。SU056 (0-5 μM，24小时) 诱导OVCAR8、SKOV3和ID8细胞的凋亡。SU056 (1-5 μM，12小时) 抑制OVCAR8细胞中YB-1、TMSB10、SUMO2和PMSB2蛋白的表达。SU056 (0.1、0.5和1 μM，48小时) 增强紫杉醇 (0.1、0.5和1 nM) [1] 的细胞毒作用。 |
| In vivo | SU056（20 mg/kg，腹腔注射）能够抑制接种ID8细胞的小鼠的肿瘤生长。SU056（10 mg/kg，腹腔注射，每日一次）与紫杉醇（5 mg/kg，每周一次，腹腔注射）联合使用，能在接种卵巢癌细胞（OVCAR8）的免疫缺陷小鼠中更显著地抑制肿瘤生长，其效果优于单独使用SU056[1]。 |
| molecular weight | 369.34 |
| Molecular formula | C20H16FNO5 |
| CAS | 2376580-08-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 45.0 mg/mL (121.8 mM), Sonication is recommended. |
| References | 1. Tailor D, et al. Y box binding protein 1 inhibition as a targeted therapy for ovarian cancer. Cell Chem Biol. 2021 Aug 19;28(8):1206-1220.e6. |