| Description | SU0268 is a potent and specific 8-Oxoguanine DNA glycosylase 1 (OGG1) inhibitor. SU0268 regulates inflammatory responses during Pseudomonas aeruginosa infection. |
| In vitro | SU0268/IACS-4759（5-20μM，48小时）联合处理的细胞比分别使用IACS-4759或SU0268处理的细胞存活率更高[1]。MTH1缺失的细胞与其对照shGFP细胞相比，对OGG1特异性抑制剂SU0268（5-10μM）的敏感性降低[1]。SU0268不与DNA结合，因此特异性地与OGG1相互作用，而非其底物[2]。SU0268通过线粒体DNA-cGAS-STING-IRF3-IFN-β轴促使I型干扰素的释放，从而减少细菌负载并阻止疾病进展[3]。 |
| In vivo | 在MH-S细胞和C57BL/6N小鼠中，SU0268预处理（10 mg/kg，经鼻腔给药）与未经SU0268预处理的对照组相比，可提高生存率[3]。 |
| molecular weight | 475.56 |
| Molecular formula | C26H25N3O4S |
| CAS | 2210228-45-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 100 mg/mL (210.28 mM), Sonication is recommended. |
| References | 1. Ling Zhang, et al. OGG1 co-inhibition antagonizes the tumor-inhibitory effects of targeting MTH1. Redox Biol. 2021 Apr;40:101848. 2. Yu-Ki Tahara, et al. Potent and Selective Inhibitors of 8-Oxoguanine DNA Glycosylase. J Am Chem Soc. 2018 Feb 14;140(6):2105-2114. 3. Shugang Qin, et al. Small-Molecule Inhibitor of 8-Oxoguanine DNA Glycosylase 1 Regulates Inflammatory Responses during Pseudomonas aeruginosa Infection. J Immunol. 2020 Oct 15;205(8):2231-2242. |