| Description | Strictosamide possesses antibacterial and antiviral activities, it also may have important effects on inflammation and inflammatory pain. |
| In vitro | 在给予20和40 mg/kg剂量下，strictosamide 显著降低了TPA诱导的小鼠耳部水肿（分别抑制了24.7%和28.1%），并且显著抑制醋酸刺激下小鼠腹腔血管通透性的增加（分别抑制了23.3%和33.4%）。同时，对于CMC-Na诱导的小鼠腹腔白细胞增多，strictosamide在所有测试剂量下显著减少了白细胞数量（分别抑制了46.0%, 49.1%, 和58.7%）。在醋酸引起的小鼠扭体实验中，20和40 mg/kg的strictosamide显著延长了疼痛潜伏期，并且在40 mg/kg剂量下显著减少了扭体次数（抑制了49.7%）。然而，在热板实验中，它并未明显改善小鼠的疼痛阈值。 |
| Synonyms | 异长春花苷内酰胺 |
| molecular weight | 498.52 |
| Molecular formula | C26H30N2O8 |
| CAS | 23141-25-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 22.5 mg/mL (45.13 mM) |
| References | 1. Synthesis and Biological Evaluation of Strictosamide Derivatives with Improved Antiviral and Antiproliferative Activities.Chem Biol Drug Des. 2015 Oct;86(4):523-30. 2. Li N , Cao L , Cheng Y , et al. In vivo anti-inflammatory and analgesic activities of strictosamide from Nauclea officinalis[J]. Pharmaceutical Biology, 2014, 52(11):1445-50. |