| Description | WNK-IN-B is an inhibitor of Wnk signalling. WNK-IN-B is a cell-permeable diaminoacridine derivative that targets the CCT domain of SPAK and OSR1 via reversible binding. WNK-IN-B selectively suppress hypotonic shock-induced WNK signaling pathway activation in mpkDCT and MOVAS (100 µM) cultures without affecting p38 MAPK phosphorylation. |
| Target activity | WNK1:34.4 μM (IC50), WNK4:16 μM (IC50) |
| Synonyms | WNK IN B, WNK-IN-B, Compound B |
| molecular weight | 333.38 |
| Molecular formula | C20H19N3O2 |
| CAS | 332922-63-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Mori T, Kikuchi E, Watanabe Y, Fujii S, Ishigami-Yuasa M, Kagechika H, Sohara E, Rai T, Sasaki S, Uchida S. Chemical library screening for WNK signalling inhibitors using fluorescence correlation spectroscopy. Biochem J. 2013 Nov 1;455(3):339-45. doi: 10.1042/BJ20130597. PubMed PMID: 23981180. |