| Description | STING-IN-3 (C-171) is an inhibitor of stimulator of interferon genes (STING). It binds to STING, inhibits its palmitoylation, and prevents the recruitment and phosphorylation of TBK1. |
| In vitro | C-171 binds to STING, inhibits its palmitoylation, and prevents the recruitment and phosphorylation of TBK1. It selectively reduces human and mouse STING-, but not RIG-I or TBK1-, mediated IFN-β reporter activity in HEK293 cells when used at concentrations ranging from 0.02 to 2 μM[1]. |
| Synonyms | C-171 |
| molecular weight | 316.35 |
| Molecular formula | C17H20N2O4 |
| CAS | 2244881-69-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 3.16 mg/mL (10 mM) |
| References | 1. Simone M Haag , Muhammet F Gulen , Luc Reymond et al. Targeting STING with covalent small-molecule inhibitors[J]. Nature, 2018. 2. Zhang H , You Q D , Xu X L . Targeting Stimulator of Interferon Genes (STING): A Medicinal Chemistry Perspective[J]. Journal of Medicinal Chemistry, 2019, XXXX(XXX). |