| Description | STING agonist-3 trihydrochloride is a selective and non-nucleotide agonist of small-molecule STING(pEC50 and pEC50 of 7.5 and 9.5, respectively), has durable anti-tumor effect and tremendous potential to improve treatment of cancer. |
| In vitro | STING agonist-3 trihydrochloride exhibits activation of STING in cells(pEC50 of 7.5), this assay is determined using a luciferase reporter assay in human embryonic kidney cells (HEK293T) co-transfected with plasmids expressing STING and the enzyme firefly luciferase driven by the interferon stimulated response element promoter.In FRET assay, STING agonist-3 trihydrochloride exhibits a pIC50 value of 9.5. This is a competition binding assay which aims to determine the binding potency of molecules to the C-terminal Domain (CTD) of human STING. |
| Synonyms | STING agonist-3 trihydrochloride (2138299-29-1 free base) |
| molecular weight | 860.19 |
| Molecular formula | C37H45Cl3N12O6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Adam Kenneth, et al. Heterocyclic amides useful as protein modulators.patent WO2017175147A1 |