| Description | Steroid sulfatase/17β-HSD1-IN-5 serves as an irreversible inhibitor of steroid sulfatase (STS) and a reversible, selective inhibitor of 7β-hydroxysteroid dehydrogenase type1 (17β-HSD1), exhibiting IC50 values of 43 nM for 17β-HSD1 and 6.2μM for 17β-HSD2. This compound is utilized in research related to metabolic diseases, particularly endometriosis [1]. |
| In vitro | Steroid sulfatase/17β-HSD1-IN-5 (Compound 5) 在0-40 μM浓度范围内，作用于HEK293与HepG2细胞48至72小时，直至其浓度达到31μM(HEK293)及23μM(HepG2)，并未对细胞活力产生影响[1]。 |
| In vivo | Steroid sulfatase/17β-HSD1-IN-5（化合物5）（皮下注射，50 mg/kg，单次给药）表现出半衰期（T 1/2）为3.82小时，并观察到最大血浆浓度（Cmax obs）为2824 nM。 |
| molecular weight | N/A |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |