| Description | Stepronin (TTPG) shows expectorant activities and inhibits airway secretion. |
| In vitro | 在犬气管上皮，Stepronin（0.1-100 µM）剂量依赖性降低异丙肾上腺素引发的短路电流值、基础分泌以及异丙肾上腺素引发的电位差值[1]。在黏膜下腺体中，Stepronin（100 µM）对异丙肾上腺素诱导的[3H]-糖结合物分泌显示出强烈抑制作用[3]。 |
| Synonyms | Prostenoglycine, Tiofacic, Tiase, TTPG |
| molecular weight | 273.33 |
| Molecular formula | C10H11NO4S2 |
| CAS | 72324-18-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 225.0 mg/mL (823.2 mM) H2O: Insoluble |
| References | 1. de Giorgi L, Habeshaw JA, Broadhurst K, Carminati P, Oxford JS. Anti-human immunodeficiency virus activity of a new immunosuppressant drug called stepronin. Transplant Proc. 1999 Dec;31(8):3257. PubMed PMID: 10616467. 2. Romano A, Di Fonso M, Mormile F, Quaratino D, Giuffreda F, Venuti A. Accelerated cell-mediated broncho-obstructive reaction to inhaled stepronin: a case report. Allergy. 1996 Apr;51(4):269-71. PubMed PMID: 8792926. 3. Yamada K, et al. An expectorant, stepronin, reduces airway secretion in vitro. Respiration. 1994;61(1):42-7. 4. de Giorgi L, Arrigoni-Martelli E, Matossian-Rogers A. Immunosuppressive effect of stepronin (TS-5010680) in mice. Transplant Proc. 1994 Dec;26(6):3513-6. PubMed PMID: 7998255. |