| Description | SRI-29132 is potent; highly permeant of the blood-brain barrier; and selective for LRRK2 kinase activity, therefore effective in attenuating pro-inflammatory responses in macrophages and in rescuing neurite retraction phenotypes in neurons. |
| Synonyms | SRI29132, SRI 29132, TPZ-11, TPZ 11, TPZ11 |
| molecular weight | 387.52 |
| Molecular formula | C18H21N5OS2 |
| CAS | 1482305-44-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Liu Z, Galemmo RA Jr, Fraser KB, Moehle MS, Sen S, Volpicelli-Daley LA, DeLucas LJ, Ross LJ, Valiyaveettil J, Moukha-Chafiq O, Pathak AK, Ananthan S, Kezar H, White EL, Gupta V, Maddry JA, Suto MJ, West AB. Unique functional and structural properties of the LRRK2 protein ATP-binding pocket. J Biol Chem. 2014 Nov 21;289(47):32937-51. doi: 10.1074/jbc.M114.602318. Epub 2014 Sep 16. PubMed PMID: 25228699; PubMed Central PMCID: PMC4239640. |