| Description | SRD5A1-IN-1 is an inhibitor of steroid 5α-reductase type 1 (SRD5A1, IC50 = 1.44 µM). SRD5A1-IN-1 lowers the production of dihydrotestosterone and shows a significant decrease in the SRD5A1 protein expression. |
| In vitro | 在HaCaT细胞中，SRD5A1-IN-1（0.5-2.5 μM）通过双重作用降低SRD5A1蛋白的表达，并调节SRD5A1，这些作用影响SRD5A1蛋白表达水平及SRD5A1酶的活性。SRD5A1-IN-1（0.5-2.5 μM）对SRD5A1的mRNA表达不产生影响，且未显示出显著的细胞毒性[1]。 |
| molecular weight | 391.27 |
| Molecular formula | C17H11F6NO3 |
| CAS | 2279077-93-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 27.5 mg/mL (70.29 mM) |
| References | 1. Lin A C K, et al. Caffeic acid N-[3, 5-bis (trifluoromethyl) phenyl] amide as a non-steroidal inhibitor for steroid 5α-reductase type 1 using a human keratinocyte cell-based assay and molecular dynamics. Scientific Reports, 2022, 12(1): 1-20. |