| Description | SR 142948A is a non-peptide antagonist of neurotensin receptor. SR 142948A affects the expression of c-Fos and has properties of antipsychotic agent. SR 142948A blocks hypothermia and analgesia induced by neurotensin. It blocks the increase in the concentration of Ca+2 induced by the activation of phospholipase C in CHO cell model. |
| Synonyms | SR142948A, SR 142948A, SR-142948A, SR142948A hydrochloride |
| molecular weight | 722.31 |
| Molecular formula | C39H52ClN5O6 |
| CAS | 184162-21-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Azmi N, Norman C, Spicer CH, Bennett GW. Effects of a neurotensin analogue (PD149163) and antagonist (SR142948A) on the scopolamine-induced deficits in a novel object discrimination task. Behav Pharmacol. 2006 Jun;17(4):357-62. PubMed PMID: 16914954. 2. Kreitel KD, Swisher CB, Behbehani MM. The effects of diphenhydramine and SR142948A on periaqueductal gray neurons and on the interactions between the medial preoptic nucleus and the periaqueductal gray. Neuroscience. 2002;114(4):935-43. PubMed PMID: 12379249. 3. Schaeffer P, Laplace MC, Bernat A, Prabonnaud V, Gully D, Lespy L, Herbert JM. SR142948A is a potent antagonist of the cardiovascular effects of neurotensin. J Cardiovasc Pharmacol. 1998 Apr;31(4):545-50. PubMed PMID: 9554803. |