| Description | SR0987 is a RORγt agonist, |
| In vitro | SR0987处理显著降低PD-1的表面表达，而desmosterol处理则无明显效果。SR0987和/或desmosterol处理倾向于提高IL17产量。SR0987还明确表现出浓度依赖性的报告基因表达诱导，EC50约为800nM。 |
| Target activity | RORγt:800 nM (EC50) |
| molecular weight | 397.7 |
| Molecular formula | C16H10ClF6NO2 |
| CAS | 303126-97-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 45 mg/mL (113.15 mM) |
| References | 1. Chang MR, et al. Synthetic RORγt Agonists Enhance Protective Immunity. ACS Chem Biol. 2016 Apr 15;11(4):1012-8. |