| Description | SQ609 is a potential anti-tuberculosis drug selected from a library of dipiperidine derivatives. SQ609 showed significant anti-tuberculous activity in mouse macrophages in vitro[1]. |
| In vitro | 在体外实验中，SQ609能显著抑制Mtb感染的巨噬细胞内部90%以上的细菌生长，在4μg/ml的浓度下对这些细胞具有毒性[1]。 |
| In vivo | SQ609（10 mg/kg；通过灌胃口服给药）完全防止了Mtb感染动物的体重减轻，并在停药后延长了治疗效果10-15天[1]。 |
| molecular weight | 346.55 |
| Molecular formula | C22H38N2O |
| CAS | 627052-25-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 1 mg/ml, Sonication is recommended. |
| References | 1. Bogatcheva E, et al. Identification of SQ609 as a lead compound from a library of dipiperidines. Bioorg Med Chem Lett. 2011;21(18):5353-5357. |