| Description | SPR519 is a potent dual inhibitor of PI3Kα and mTOR kinases with IC50 (PI3Kalpha) = 30 nM and IC50 (mTOR) = 10 nM. SPR519 exhibits an EC50 of low sub-micromolar range among various tested cancer cell lines such as A2780 (0.23 μM), PC3 (0.48 μM), and SKOV3 (0.50 μM). |
| molecular weight | 427.48 |
| Molecular formula | C19H21N7O3S |
| CAS | 1391923-59-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |