| Description | Splenopentin diacetate (Splenin pentapeptide (32-36)) is a synthetic immunomodulating peptide and can reproduce the biological activities of splenin and thymic hormone thymopoietin. |
| In vitro | Splenopentin diacetate（0.1 ng/mL-10 μg/mL）在小鼠体内经伽玛射线照射后，能促进T细胞和B细胞前体细胞的表型分化，以增加抗体生成细胞的数量[2]。 |
| In vivo | Splenopentin diacetate (0.01-100 μg; i.p.) 对小鼠的神经肌肉传导无明显影响[2]。Splenopentin diacetate (1 mg/kg; i.p.) 促进了Langerhans细胞的招募，并导致经过Cyclophosphamide或Dexamethasone处理的雌性Balb/c/Bln小鼠皮肤中Langerhans细胞（LC）密度恢复到预处理水平[3]。 |
| Synonyms | Thymopoietin III pentapeptide (32-36), SP5, Splenopentin Acetate, 醋酸脾脏五肽, Splenin pentapeptide (32-36), Arg-lys-glu-val-tyr |
| molecular weight | 753.84 |
| Molecular formula | C33H55N9O11 |
| CAS | 105184-37-0 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | H2O: Insoluble DMSO: Soluble |
| References | 1. Rastogi A, et, al. Augmentation of human natural killer cells by splenopentin analogs. FEBS Lett. 1993 Feb 8;317(1-2):93-5. 2. Audhya T, et, al. Contrasting biological activities of thymopoietin and splenin, two closely related polypeptide products of thymus and spleen. Proc Natl Acad Sci U S A. 1984 May;81(9):2847-9. 3. Gruner S, et, al. Stimulation of the recruitment of epidermal Langerhans cells by splenopentin. Arch Dermatol Res. 1990;281(8):526-9. 4. Singh VK, et, al. Thymopentin and splenopentin as immunomodulators. Current status. Immunol Res. 1998;17(3):345-68. |