| Description | SPI--112Me, a prodrug of SPI-112, preferentially inhibits the PTPase activity of Shp2 over Shp1 and PTP1B by more than 20-fold in cell-free assays. |
| molecular weight | 482.48 |
| Molecular formula | C23H19FN4O5S |
| CAS | 1243685-62-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 55 mg/mL (113.99 mM) |
| References | 1. Win-Piazza, H., Schneeberger, V., Chen, L., Pernazza, D., Lawrence, H., & Sebti, S. et al. (2012). Enhanced anti-melanoma efficacy of interferon alfa-2b via inhibition of Shp2. Send To Cancer Lett, 320(1), 81-5. doi: 10.1016/j.canlet.2012.01.034 |