| Description | SPEN-IN-1 binding suppresses histone H3K27 trimethylation and blocks initiation of X-chromosome inactivation. SPEN-IN-1 binding reduces the conformational space of RepA and displaces cognate interacting protein factors including PRC2 and SPEN. |
| molecular weight | 416.47 |
| Molecular formula | C27H20N4O |
| CAS | 2863686-82-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: Insoluble DMSO: 50 mg/mL (120.06 mM), Sonication is recommended. Ethanol: 20 mg/mL (48.02 mM) |
| References | 1. Aguilar R, et al. Targeting Xist with compounds that disrupt RNA structure and X inactivation. Nature. 2022 Apr;604(7904):160-166. |